Innovative Drug Discovery and Nanotechnology (Track)
Electrochemical Reduction of Co(II)-Disulfiram Complex at the Surface of Glassy Carbon Electrode in Mixed Different Non-Aqueous Media
Sohrab Ershad
Departmnet of Chemistry
Payame noor university
Marand, Iran
Abstract:
Dsulfiram (bis(diethylthicarbamoyl)disulfide or Antabuse is a dithiocarbamate drug used clinically in the treatment of alcoholism [1]. It inhibits the enzyme aldehyde dehydrogenase that leads to the accumulation of acetaldehyde, a byproduct of alcohol metabolism, producing unpleasant and aversive side effects on alcohol consumption [2-3]. It addition disulfiram, inhibits dopamine-β-hydroxylate (DBH) [4]. The thiocarbamate alcoholism drug disulfiram blocks the P-glycoprotein extrusion pump, inhibits the transcription factor nuclear factor-nβ, sensitizes tumors to chemotherapy, reduces angiogenesis, and inhibits tumor growth in mice [5].
In this investigation, the redox properties of a Co(II)- Disulfiram complex has been examined using cyclic voltametry in different non-aqueous media such as acetonitrile, dichlromethane and mixed solvents at the surface of gold , pelatin and glassy carbon electrodes. It has been found that, this compound exhibits one electron reduction peak with the EC catalytic mechanism. The charge transfer coefficients (α) and the diffusion coefficients (D values) for this compound in various solvents were obtained on the basis of voltamograms. Effect of dielectric constants of solvents on redox behavior of complex was investigated.
